منابع مشابه
The RASSF1A tumor suppressor.
RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigen...
متن کاملAssociation of RASSF1A Promoter Methylation
Lung cancer is the most frequent cancer worldwide still. There were more than 1.8 million new cases (13% of total cancer incidence) and almost 1.6 million deaths (20% of total cancer mortality), as estimated in 2012 (WIL, D2014). Moreover, Lung cancer is the leading cause of cancer death in men in 87 countries and in women in 26 countries. Despite the advent of new diagnostic techniques, most l...
متن کاملHippo and rassf1a Pathways: A Growing Affair
First discovered in Drosophila, the Hippo pathway regulates the size and shape of organ development. Its discovery and study have helped to address longstanding questions in developmental biology. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the Yki protein (YAP and TAZ in mammals), a transcriptional coactivator of target gene...
متن کاملThe Role of RASSF1A Methylation in Cancer
Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of function may be mediated by irreversible processes such as gene deletion or mutation. Alternatively tumour suppressor genes may be inactivated via epigenetic processes a reversible mechanism that promises to be more amenable to treatment by therapeutic agents. The CpG dinucleotide is under-represented i...
متن کاملTumor susceptibility of Rassf1a knockout mice.
The human Ras association domain family 1 (RASSF1) gene is located at 3p21.3 in an area that is believed to harbor at least one important tumor suppressor gene. The two major isoforms of RASSF1, RASSF1A and RASSF1C, are distinguished by alternative NH(2)-terminal exons and the two transcripts initiate in two separate CpG islands. RASSF1A is one of the most frequently inactivated genes described...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2011
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.2.3.16286